Investigation of the Spatial Resolution of MR-Based Polymer Gel Dosimetry versus Film Densitometry using Dose Modulation Transfer Function

Introduction: The conventional methods of dosimetry are not capable of dosimetry in such a small volume of less than one cubic millimeter. Although the polymer gel dosimetry method based on magnetic resonance imaging (MRI) could achieve three dimensional dosimetry with high resolution, a spatial resolution evaluation based on gel dose modulation transfer function has not been investigated yet. Therefore, in this study, the spatial resolution of two systems of film densitometry and polymer gel dosimetry based on MRI has been evaluated by using the dose modulation transfer function (DMTF). Material and Methods: Kodak therapy verification films and MAGICA polymer gel samples were positioned below a brass absorption grid with different periodic slices (a/2= 280, 525, 1125 μm), which was placed in a water bath container to avoid regions of dose build-up just below the absorption grid and then irradiated with Cobalt-60 photons on a Theratron external-beam treatment unit. Dose variation under the brass grid was determined using a calibration curve, while transverse relaxation time (T2) as the selective parameter in a dose image based on multiple echo MRI with 1.5 Tesla GE Signa Echo Speed system (FOV=10 cm, matrix size=512 ×512, pixel size =0.199×0.199 mm2, TE = 20, 40, 60, 80 ms, TR=4200 ms, NEX = 4, slice thickness=2 mm, gap=1 mm) was calculated. DMTF from the modulation depths of T2 and variation in film optical density after calibration would be achieved. The results of polymer gel were compared with film. Results: After deriving the dose distribution profile under the absorption grid, minima and maxima at the smallest period of a = 560 μm could scarcely be resolved, but the modulations due to a=2250 μm and a = 1050 μm grids could be discerned. The modulation depth for a=2250 μm grid was set to 100% and the other modulations were subsequently referred to this maximum modulation. For film densitometry at a = 1050 μm, the modulation depth was reduced to 35% (30% for MR based polymer gel dosimetry; MRPD) and at a = 560 μm the modulation in dose was reduced to about 9% of the maximum amplitude (7% for MRPD). The DMTF for the two systems at 200 micron spatial resolution for the 2250, 1050 and 560 μm grids (0.4, 0.9 and 1.7 line pairs per mm) were equal to 1, 0.35 and 0.09 for film densitometry and 1, 0.30 and 0.07 for polymer gel. Discussion and Conclusions: Based on the results of this study, the decrease in DMTF at higher frequencies in a system in its operating resolution limit, is dependent on the type of the dosimetry system. Therefore, the assessment of DMTF for film densitometry system implied a higher spatial resolution in comparison with polymer gel dosimetry at 200 micron spatial resolution