Rational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a second polymer (carbomer, guar or xanthan gum). The gels were characterised using in vitroadhesion, spreadability and leakage potential studies, as well as rheological measurements (stress and frequency sweep tests) and the effect of dilution with simulated vaginal fluid (SVF) on spreadability. Results were analysed using analysis of variance and multiple factor analysis. The combination of polymers enhanced adhesion of both primary gelling agen...
Maintaining insoluble plant-based ingredients in suspension and ensuring long-term physical stabilit...
Current vaginal formulations, such as gels and pessaries, have limitations, including poor retention...
The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready...
Rational design of vaginal drug delivery formulations requires special attention to vehicle properti...
Purpose: Alternate formulation strategies need to be devised for improving the absorption and bioava...
Background/Aim. Vinegar is one of the main international traditional nutraceuticals, and it has been...
This investigation describes the formulation and characterization of rheologically structured vehicl...
Aim. The purpose of the work is to determine the bioadhesion indices of vaginal gel with resveratrol...
Vaginal formulations for the prevention of sexually transmitted infections are currently gaining imp...
Gels containing chlorhexidine, based on hydroxyethylcellulose or its mixtures with either hydroxypro...
Purpose: Alternate formulation strategies need to be devised for improving the absorption and bioava...
Sodium alginate and poloxamer 407 were both studied in order to design a hydrogel-based delivery sys...
PubMed ID: 12729833Bioadhesive tablet formulations have been developed for mucosal application. Sixt...
The aim of our study was to prepare clomiphene citrate gel formulations that possess appropriate mec...
The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazo...
Maintaining insoluble plant-based ingredients in suspension and ensuring long-term physical stabilit...
Current vaginal formulations, such as gels and pessaries, have limitations, including poor retention...
The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready...
Rational design of vaginal drug delivery formulations requires special attention to vehicle properti...
Purpose: Alternate formulation strategies need to be devised for improving the absorption and bioava...
Background/Aim. Vinegar is one of the main international traditional nutraceuticals, and it has been...
This investigation describes the formulation and characterization of rheologically structured vehicl...
Aim. The purpose of the work is to determine the bioadhesion indices of vaginal gel with resveratrol...
Vaginal formulations for the prevention of sexually transmitted infections are currently gaining imp...
Gels containing chlorhexidine, based on hydroxyethylcellulose or its mixtures with either hydroxypro...
Purpose: Alternate formulation strategies need to be devised for improving the absorption and bioava...
Sodium alginate and poloxamer 407 were both studied in order to design a hydrogel-based delivery sys...
PubMed ID: 12729833Bioadhesive tablet formulations have been developed for mucosal application. Sixt...
The aim of our study was to prepare clomiphene citrate gel formulations that possess appropriate mec...
The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazo...
Maintaining insoluble plant-based ingredients in suspension and ensuring long-term physical stabilit...
Current vaginal formulations, such as gels and pessaries, have limitations, including poor retention...
The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready...