Conformational switch of syntaxin-1 controls synaptic vesicle fusion
- Gerber, S.H.
- Rah, J.C.
- Liu, X.
- de Wit, H.
- Dulubova, I.
- Meyer, A.C.
- Rizo, J.
- Arancillo, M.
- Hammer, R.E.
- Verhage, M.
- Rosenmund, C.
- Südhof, T.C.
Publication date
January 2008
DOI Publisher
American Association for the Advancement of Science (AAAS) ISSN
0036-8075 Citation count (estimate)
182Abstract
During synaptic vesicle fusion, the soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) protein syntaxin-1 exhibits two conformations that both bind to Munc18-1: a "closed" conformation outside the SNARE complex and an "open" conformation in the SNARE complex. Although SNARE complexes containing open syntaxin-1 and Munc18-1 are essential for exocytosis, the function of closed syntaxin-1 is unknown. We generated knockin/knockout mice that expressed only open syntaxin-1B. Syntaxin-1
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