Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.
- Redout, E.M.
- Wagner, M.J.
- Zuidwijk, M.J.
- Boer, C.
- Musters, R.J.P.
- van Hardeveld, C.
- Paulus, W.J.S.
- Simonides, W.S.
Publication date
January 2007
DOI ISSN
0008-6363 Citation count (estimate)
103Abstract
Objective: Reactive oxygen species (ROS) have been implicated in the progression of ventricular hypertrophy to congestive heart failure. However, the source of increased oxidative stress in cardiomyocytes remains unclear. Methods: Here we examined NADPH oxidase and mitochondria as sources of ventricular ROS production in a rat model of right-ventricular (RV) failure (CHF) induced by pulmonary arterial hypertension (PAH). Results: Western analysis showed increased expression of the catalytic subunit gp9
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