We report heritabilities for individual differences in female pubertal development at the age of 12. Tanner data on breast and pubic hair development in girls and data on menarche were obtained from a total of 184 pairs of monozygotic and dizygotic twins. Genetic correlations were estimated to determine to what extent the same genes are involved in different aspects of physical development in puberty. A Bayesian estimation approach was taken, using Markovchain Monte Carlo simulation to estimate model parameters. All three phenotypes were to a significant extent heritable and showed high genetic correlations, suggesting that a common set of genes is involved in the timing of puberty in general. However, gonadarche (menarche and breast develo...
The aim of this study was to estimate the heritability of variation in testosterone levels in 12-yea...
Genes that influence a phenotype earlier in life may differ from those influencing the same phenotyp...
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, i...
Puberty is the physical transition in the maturation process experienced by adolescents. It is a com...
Entering puberty, children undergo large changes in their physiology and physical appearance which w...
Understanding the regulation of puberty timing has relevance to developmental and human biology and ...
The timing of puberty is complex, possibly involving many genetic factors that may interact with env...
Secular trends towards earlier puberty, possibly caused by new environmental triggers, provide a bas...
Andrew Hattersley is a collaborator on this journal article/project.Little is known about genes regu...
Lyle Palmer is a member of The Early Growth Genetics (EGG) ConsortiumLittle is known about genes reg...
The timing of puberty is complex, possibly involving many genetic factors that may interact with env...
Previous genetic research has identified many human genes with allelic variation that are associated...
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated wit...
The aim of this study was to estimate the heritability of variation in testosterone levels in 12-yea...
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated wit...
The aim of this study was to estimate the heritability of variation in testosterone levels in 12-yea...
Genes that influence a phenotype earlier in life may differ from those influencing the same phenotyp...
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, i...
Puberty is the physical transition in the maturation process experienced by adolescents. It is a com...
Entering puberty, children undergo large changes in their physiology and physical appearance which w...
Understanding the regulation of puberty timing has relevance to developmental and human biology and ...
The timing of puberty is complex, possibly involving many genetic factors that may interact with env...
Secular trends towards earlier puberty, possibly caused by new environmental triggers, provide a bas...
Andrew Hattersley is a collaborator on this journal article/project.Little is known about genes regu...
Lyle Palmer is a member of The Early Growth Genetics (EGG) ConsortiumLittle is known about genes reg...
The timing of puberty is complex, possibly involving many genetic factors that may interact with env...
Previous genetic research has identified many human genes with allelic variation that are associated...
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated wit...
The aim of this study was to estimate the heritability of variation in testosterone levels in 12-yea...
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated wit...
The aim of this study was to estimate the heritability of variation in testosterone levels in 12-yea...
Genes that influence a phenotype earlier in life may differ from those influencing the same phenotyp...
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, i...