Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels
- Beekman, M.
- Heijmans, B.T.
- Martin, N.G.
- Whitfield, J.B.
- Pedersen, N.L.
- DeFaire, U.
- Snieder, H.
- Lakenberg, N.
- de Knijff, P.
- Frants, R.R.
- van Ommen, G.J.B
- Kluft, C.
- Vogler, G.P.
- Slagboom, P.E.
- Boomsma, D.I.
Publication date
January 2003
DOIAbstract
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs
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