YidC was recently shown to play an important role in the assembly of inner membrane proteins (IMPs) both in conjunction with and separate from the Sec-translocon. Little is known about the biogenesis and structural and functional properties of YidC, itself a polytopic IMP. Here we analyze the targeting and membrane integration of YidC using in vivo and in vitro approaches. The combined data indicate that YidC is targeted by the signal recognition particle and inserts at the SecAYEG-YidC translocon early during biogenesis, unlike its mitochondrial homologue Oxalp. In addition, YidC is shown to be relatively abundant compared with other components involved in IMP assembly and is predominantly localized at the poles of the cell
Little is known about the quality control of proteins upon integration in the inner membrane of Esch...
In Escherichia coli, both secretory and inner membrane proteins initially are targeted to the core S...
Escherichia coli inner membrane proteins (IMPs) use different pathways for targeting and membrane in...
In the bacterium Escherichia coli, inner membrane proteins (IMPs) are generally targeted through the...
Inner membrane proteins (IMPs) of Escherichia coli use different pathways for membrane targeting and...
YidC has been identified recently as an evolutionary conserved factor that is involved in the integr...
Escherichia coli YidC is a polytopic inner membrane protein that plays an essential and versatile ro...
YidC has an essential but poorly defined function in membrane protein insertion and folding in bacte...
The YidC protein fulfills a dual and essential role in the assembly of inner membrane proteins in Es...
Gram-negative bacteria such as Escherichia coli are surrounded by two membranes, the inner membrane ...
Montpellier Cedex 5, France The YidC protein fulfills a dual and essential role in the assembly of i...
Bacteria, mitochondria and chloroplasts harbour factors that facilitate the insertion, folding and a...
The mechanosensitive channel with large conductance (MscL) of Escherichia coli is formed by a homope...
The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IM...
The mechanosensitive channel with large conductance (MscL) of Escherichia coli is formed by a homope...
Little is known about the quality control of proteins upon integration in the inner membrane of Esch...
In Escherichia coli, both secretory and inner membrane proteins initially are targeted to the core S...
Escherichia coli inner membrane proteins (IMPs) use different pathways for targeting and membrane in...
In the bacterium Escherichia coli, inner membrane proteins (IMPs) are generally targeted through the...
Inner membrane proteins (IMPs) of Escherichia coli use different pathways for membrane targeting and...
YidC has been identified recently as an evolutionary conserved factor that is involved in the integr...
Escherichia coli YidC is a polytopic inner membrane protein that plays an essential and versatile ro...
YidC has an essential but poorly defined function in membrane protein insertion and folding in bacte...
The YidC protein fulfills a dual and essential role in the assembly of inner membrane proteins in Es...
Gram-negative bacteria such as Escherichia coli are surrounded by two membranes, the inner membrane ...
Montpellier Cedex 5, France The YidC protein fulfills a dual and essential role in the assembly of i...
Bacteria, mitochondria and chloroplasts harbour factors that facilitate the insertion, folding and a...
The mechanosensitive channel with large conductance (MscL) of Escherichia coli is formed by a homope...
The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IM...
The mechanosensitive channel with large conductance (MscL) of Escherichia coli is formed by a homope...
Little is known about the quality control of proteins upon integration in the inner membrane of Esch...
In Escherichia coli, both secretory and inner membrane proteins initially are targeted to the core S...
Escherichia coli inner membrane proteins (IMPs) use different pathways for targeting and membrane in...