Abstract The use of mobile phone data provides new spatio-temporal tools for improving urban planning, and for reducing inefficiencies in present-day urban systems. Data from mobile phones, originally intended as a communication tool, are increasingly used as innovative tools in geography and social sciences research. Empirical studies on complex city systems from human-centred and urban dynamics perspectives provide new insights to develop promising applications for supporting smart city initiatives. This paper provides a comprehensive review and a typology of spatial studies on mobile phone data, and highlights the applicability of such digital data to develop innovative applications for enhanced urban management