THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY)

<p>The combination of risk factors that make up a metabolic syndrome increases the risk of cardiovascular disease and type 2 diabetes. In the presence of insulin resistance the effects of risk factors combine, thereby increasing the probability of the development of cardiovascular disease and its complications.</p><p><strong>Aim.</strong> To study the effect of insulin resistance on the formation and progression of metabolic syndrome components on the basis of a 5-year follow-up.</p><p><strong>Material and methods.</strong> An outpatient examination of clinically healthy patients aged 20-65 years (n=711; 327 men and 384 women) was conducted. The average body mass index did not exceed 34.5 kg/m2. Biochemical blood analysis was performed to assess the state of lipid and carbohydrate metabolism. Insulin resistance was diagnosed using HOMAIR&gt;2.6.</p><p><strong>Results.</strong> It has been detected that patients with insulin resistance have significantly higher incidence of the combination of three or more components of the metabolic syndrome (p&lt;0.01). The incidence of multicomponent syndrome among the examined patients with insulin resistance was 69.7%, which is 1.8 times higher than in patients with initially preserved tissue sensitivity to insulin.</p><p><strong>Conclusion.</strong> The follow-up study of patients with insulin resistance shows that in the absence of correction of metabolic disorders, the development of multicomponent disorders that make up a metabolic syndrome occurs.