Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
- Cornelis, M.C.
- Byrne, E.M.
- Esko, T.
- Nalls, M.A.
- Ganna, A.
- Paynter, N.
- Monda, K.L.
- Amin, N.
- Fischer, K.
- Renstrom, F.
- Ngwa, J.S.
- Huikari, V.
- Cavadino, A.
- Nolte, I.M.
- Teumer, A.
- Yu, K.
- Marques-Vidal, P.
- Rawal, R.
- Manichaikul, A.
- Wojczynski, M.K.
- Vink, J.M.
- Zhao, J.H.
- Burlutsky, G.
- Lahti, J.
- Mikkilä, V.
- Lemaitre, R.N.
- Eriksson, J.
- Musani, S.K.
- Tanaka, T.
- Geller, F.
- Luan, J.
- Hui, J.
- Mägi, R.
- Dimitriou, M.
- Garcia, M.E.
- Ho, WrightW.K.
- Wright, M.J.
- Rose, L.M.
- Magnusson, P.K.E.
- Pedersen, N.L.
- Couper, D.
- Oostra, B.A.
- Hofman, A.
- Ikram, M.A.
- Tiemeier, H.
- Uitterlinden, A.G.
- van Rooij, F.J.A.
- Barroso, I.
- Johansson, I.
- Xue, L.
- Kaakinen, M.
- Milani, L.
- Power, C.
- Snieder, H.
- Stolk, R.P.
- Baumeister, S.E.
- Biffar, R.
- Gu, F.
- Bastardot, F.
- Kutalik, Z.
- Jacobs, D.R.
- Forouhi, N.G.
- Mihailov, E.
- Lind, L.
- Lindgren, C.
- Michaëlsson, K.
- Morris, A.
- Jensen, M.
- Khaw, K.T.
- Luben, R.N.
- Wang, J.J.
- Männisto, S.
- Perälä, M.M.
- Kähönen, M.
- Lehtimäki, T.
- Viikari, J.
- Mozaffarian, D.
- Mukamal, K.
- Psaty, B.M.
- Döring, A.
- Heath, A.C.
- Montgomery, G.W.
- Dahmen, N.
- Carithers, T.
- Tucker, K.L.
- Ferrucci, L.
- Boyd, H.A.
- Melbye, M.
- Treur, J.L.
- Mellström, D.
- Hottenga, J.J.
- Prokopenko, I.
- Tönjes, A.
- Deloukas, P.
- Kanoni, S.
- Lorentzon, M.
- Houston, D.K.
- Liu, Y.
- Danesh, J.
- Rasheed, A.
- Mason, M.A.
- Zonderman, A.B.
- Franke, L.
- Kristal, B.S.
- Karjalainen, J.
- Reed, D.R.
- Westra, H.J.
- Evans, M.K.
- Saleheen, D.
- Harris, T.B.
- Dedoussis, G.
- Curhan, G.
- Stumvoll, M.
- Beilby, J.
- Pasquale, L.R.
- Feenstra, B.
- Bandinelli, S.
- Ordovas, J.M.
- Chan, A.T.
- Peters, U.
- Ohlsson, C.
- Gieger, C.
- Martin, N.G.
- Waldenberger, M.
- Siscovick, D.S.
- Raitakari, O.
- Eriksson, J.G.
- Mitchell, P.
- Hunter, D.J.
- Kraft, P.
- Rimm, E.B.
- Boomsma, D.I.
- Borecki, I.B.
- Loos, R.J.F.
- Wareham, N.J.
- Vollenweider, P.
- Caporaso, N.
- Grabe, H.J.
- Neuhouser, M.L.
- Wolffenbuttel, B.H.R.
- Hu, F.B.
- Hyppönen, E.
- Järvelin, M.R.
- Cupples, L.A.
- Franks, P.W.
- Ridker, P.M.
- van Duijn, C.M.
- Heiss, G.
- Metspalu, A.
- North, K.E.
- Ingelsson, E.
- Nettleton, J.A.
- van Dam, R.M.
- Chasman, D.I.
DOIAbstract
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91 462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ∼30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and biological relevance. Eight loci, including six novel loci, met GW significance (log 10 Bayes factor (BF)>5.64) with per-a...
Add to ORKG