Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial
- van Wijngaarden, J.P.
- Swart, K.M.A.
- Enneman, A.W.
- Dhonukshe-Rutten, R.A.M.
- van Dijk, S.C.
- van der Ham, A.C.
- Brouwer-Brolsma, E.M.
- van der Zwaluw, N.L.
- Sohl, L.
- van Meurs, J.B.J.
- Zillikens, M.C.
- van Schoor, N.M.
- van der Velde, N.
- Brug, J.
- Uitterlinden, A. G.
- Lips, P.T.A.M.
- de Groot, L.C.P.G.
Publication date
January 2014
DOI Publisher
American Society for Nutrition ISSN
0002-9165 Citation count (estimate)
35Abstract
Background: Elevated plasma homocysteine concentrations are a risk factor for osteoporotic fractures. Lowering homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk
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