Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children
- Blokhuis, M.M.
- Middeldorp, C.M.
- Kan, K.J.
- Abdellaoui, A.
- van Beijsterveldt, C.E.M.
- Ehli, E.A.
- Davies, G.E.
- Scheet, P.
- Xiao, X.
- Hudziak, J.J.
- Hottenga, J.J.
- Neale, B.M.
- Boomsma, D.I.
Publication date
January 2014
DOI Publisher
Elsevier BV ISSN
0890-8567 Citation count (estimate)
19Abstract
Objective: Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. These same traits that define ADHD are variable in the general population, and the clinical diagnosis may represent the extreme end of a continuous distribution of inattentive and hyperactive behaviors. This hypothesis can be tested by assessing the predictive value of polygenic risk scores derived from a discovery sample of ADHD patients in a target sample from the general population with continuous scores of inattention and hyperactivity. In addition, the genetic overlap between ADHD and continuous ADHD scores can be tested across rater and age
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