Myelinating glia cells support axon survival and functions through mechanisms independent of myelination, and their dysfunction leads to axonal degeneration in several diseases. In amyotrophic lateral sclerosis (ALS), spinal motor neurons undergo retrograde degeneration, and slowing of axonal transport is an early event that in ALS mutant mice occurs well before motor neuron degeneration. Interestingly, in familial forms of ALS, Schwann cells have been proposed to slow disease progression. We demonstrated previously that Schwann cells transfer polyribosomes to diseased and regenerating axons, a possible rescue mechanism for disease-induced reductions in axonal proteins. Here, we investigated whether elevated levels of axonal ribosomes are a...
Superoxide dismutase 1 (SOD1), a ubiquitously expressed enzyme, detoxifies superoxide radicals and p...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons causing a...
Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spi...
Myelinating glia cells support axon survival and functions through mechanisms independent of myelina...
Myelinating glia cells support axon survival and functions through mechanisms independent of myelina...
Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system...
<p>A, sural nerve biopsy of a control person having no neurological symptoms, showing a myelinated a...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneur...
Glial cells were previously proven capable of trafficking polyribosomes to injured axons. However, t...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
BACKGROUND: ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involve...
Background: ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involve...
Amyotrophic lateral sclerosis (ALS) is a devastating disorder involving loss of movement due to dege...
Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrop...
Summary: Spinal motor axons traverse large distances to innervate target muscles, thus requiring loc...
Superoxide dismutase 1 (SOD1), a ubiquitously expressed enzyme, detoxifies superoxide radicals and p...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons causing a...
Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spi...
Myelinating glia cells support axon survival and functions through mechanisms independent of myelina...
Myelinating glia cells support axon survival and functions through mechanisms independent of myelina...
Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system...
<p>A, sural nerve biopsy of a control person having no neurological symptoms, showing a myelinated a...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneur...
Glial cells were previously proven capable of trafficking polyribosomes to injured axons. However, t...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss ...
BACKGROUND: ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involve...
Background: ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involve...
Amyotrophic lateral sclerosis (ALS) is a devastating disorder involving loss of movement due to dege...
Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrop...
Summary: Spinal motor axons traverse large distances to innervate target muscles, thus requiring loc...
Superoxide dismutase 1 (SOD1), a ubiquitously expressed enzyme, detoxifies superoxide radicals and p...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons causing a...
Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spi...