The association between low vitamin D and depressive disorders
- Milaneschi, Y.
- Hoogendijk, W.J.G.
- Lips, P.T.A.M.
- Heijboer, A.C.
- Schoevers, R.
- van Hemert, A.M.
- Beekman, A.T.F.
- Smit, J.H.
- Penninx, B.W.J.H.
DOIAbstract
It has been hypothesized that hypovitaminosis D is associated with depression but epidemiological evidence is limited. We investigated the association between depressive disorders and related clinical characteristics with blood concentrations of 25-hydroxyvitamin D 25(OH)D in a large cohort. The sample consisted of participants (aged 18-65 years) from the Netherlands Study of Depression and Anxiety (NESDA) with a current (N=1102) or remitted (N=790) depressive disorder (major depressive disorder, dysthymia) defined according to DSM-IV criteria, and healthy controls (N=494). Serum levels of 25(OH)D measured and analyzed in multivariate analyses adjusting for sociodemographics, sunlight, urbanization, lifestyle and health. Of the sample, 33.6...
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