Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy
- Witjas-Paalberends, E.R.
- Piroddi, N.
- Stam, C.J.
- van Dijk, S.J.
- Oliviera, V.S.
- Ferrara, C.
- Scellini, B.
- Hazebroek, M.
- ten Cate, F.J.
- van Slegtenhorst, M.
- dos Remedios, C.
- Niessen, H.W.M.
- Tesi, C.
- Stienen, G.J.M.
- Heymans, S.
- Michels, M.
- Poggesi, C.
- van der Velden, J.
Publication date
January 2013
DOIAbstract
Aims Familial hypertrophic cardiomyopathy (HCM), frequently caused by sarcomeric gene mutations, is characterized by cellular dysfunction and asymmetric left-ventricular (LV) hypertrophy.We studied whether cellular dysfunction is due to an intrinsic sarcomere defect or cardiomyocyte remodelling. Methods and results Cardiac samples from 43 sarcomere mutation-positive patients (HC
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