Injury markers predict time to dementia in subjects with MCI and amyloid pathology
- van Rossum, I.A.
- Vos, S.J.B.
- Burns, L.
- Knol, D.L.
- Scheltens, P.
- Soininen, H.
- Wahlund, L.O.
- Hampel, H.
- Tsolaki, M.
- Minthon, L.
- L'Italien, G.
- van der Flier, W.M.
- Teunissen, C.E.
- Blennow, K.
- Barkhof, F.
- Rueckert, D.
- Wolz, R.
- Verhey, F.
- Visser, P.J.
Publication date
January 2012
DOI Publisher
Ovid Technologies (Wolters Kluwer Health)Abstract
Objectives: Alzheimer disease (AD) can now be diagnosed in subjects with mild cognitive impairment (MCI) using biomarkers. However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects with MCI and evidence of amyloid pathology. Methods: We pooled subjects from the VU University Medical Center Alzheimer Center and the Development of Screening Guidelines and Criteria for Predementia Alzheimer's Disease (DESCRIPA) study. We included subjects with MCI, an abnormal level of β-amyloi
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