Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
- Hartz, S.M.
- Short, S.E.
- Saccone, N.L.
- Culverhouse, R.
- Chen, L.
- Schwantes-An, T.H.
- Coon, H.
- Han, Y.
- Stephens, S.H.
- Sun, J.
- Chen, X.
- Ducci, F.
- Dueker, N.
- Franceschini, N.
- Frank, J.
- Geller, F.
- Gubjartsson, D.
- Hansel, N.N.
- Jiang, C.
- Keskitalo-Vuokko, K.
- Liu, Z.
- Lyytikäinen, L.P.
- Michel, M.
- Rawal, R.
- Rosenberger, A.
- Scheet, P.
- Shaffer, J.R.
- Teumer, A.
- Thompson, J.R.
- Vink, J.M.
- Vogelzangs, N.
- Wenzlaff, A.S.
- Wheeler, W.
- Xiao, X.
- Yang, B.Z.
- Aggen, S.H.
- Balmforth, A.J.
- Baumeister, S.E.
- Beaty, T.
- Bennett, S.
- Bergen, A.W.
- Boyd, H.A.
- Broms, U.
- Campbell, H.
- Chatterjee, N.
- Chen, J.
- Cheng, Y.C.
- Cichon, S.
- Couper, D.
- Cucca, F.
- Dick, D.M.
- Foroud, T.
- Furberg, H.
- Giegling, I.
- Gu, F.
- Hall, A.S.
- Hällfors, J.
- Han, S.
- Hartmann, A. M.
- Hayward, C.
- Heikkilä, K.
- Hewitt, J.K.
- Hottenga, J.J.
- Jensen, M.K.
- Jousilahti, P.
- Kaakinen, M.
- Kittner, S.J.
- Konte, B.
- Korhonen, T.
- Landi, M.T.
- Laatikainen, T.
- Leppert, M.
- Levy, S.M.
- Mathias, R.A.
- McNeil, D.W.
- Medland, S.E.
- Montgomery, G.W.
- Muley, T.
- Murray, T.
- Nauck, M.
- North, K.
- Pergadia, M.L.
- Polasek, O.
- Ramos, E.M.
- Ripatti, S.
- Risch, A.
- Ruczinski, I.
- Rudan, I.
- Salomaa, V.
- Schlessinger, D.
- Styrkársdóttir, U.
- Terracciano, A.
- Uda, M.
- Willemsen, G.
- Wu, X.
- Abecasis, G.R.
- Barnes, K.
- Bickeböller, H.
- Boerwinkle, E.
- Boomsma, D.I.
- Caporaso, N.
- Duan, J.
- Edenberg, H.J.
- Francks, C.
- Gejman, P.V.
- Gelernter, J.
- Grabe, H.J.
- Hops, H.
- Jarvelin, M.R.
- Viikari, J.
- Kähönen, M.
- Kendler, K.S.
- Lehtimäki, T.
- Levinson, D.F.
- Marazita, M.L.
- Marchini, J.
- Melbye, M.
- Mitchell, B.D.
- Murray, J.C.
- Nöthen, M.M.
- Penninx, B.W.J.H.
- Raitakari, O.
- Rietschel, M.
- Rujescu, D.
- Samani, N.J.
- Sanders, A.R.
- Schwartz, A.G.
- Shete, S.
- Shi, J.
- Spitz, M.
- Stefansson, K.
- Swan, G.E.
- Thorgeirsson, T.E.
- Völzke, H.
- Wei, Q.
- Wichmann, H.E.
- Amos, C.I.
- Breslau, N.
- Cannon, D.S.
- Ehringer, M.
- Grucza, R.A.
- Hatsukami, D.
- Heath, A.C.
- Johnson, E.O.
- Kaprio, J.
- Madden, P.
- Martin, N.G.
- Stevens, V.L.
- Stitzel, J.A.
- Weiss, R.B.
- Kraft, P.
- Bierut, L.J.
DOIAbstract
Context: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. Objective: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. Data Sources: Primary data. Study Selection: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DataExtraction: Uniform statistical analysis scripts were runlocally. Startingwith94 050ever-smokersfrom43studies, we extracted the heavy smokers (CPD>20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33 348. Each study was stratified into early-onset smokers (age at onset ≤16 year...
Add to ORKG