Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here we used Ercc1 mutant mice, which are impaired in multiple DNA repair systems and consequently show accelerated aging and progressive memory deficits, to identify changes in the levels of hippocampal synaptic proteins that potentially underlie these age-dependent deficits. Aged Ercc1 mutant mice show normal gross hippocampal dendritic morphology and synapse numbers, and Ercc1 mutant hippocampal neurons displayed normal outgrowth and synapse formation in vitro. However, using isobaric tag for relative and absolute quantification (iTRAQ) of hippocampal synaptic proteins at two different ages, postnatal days 28 and 112, we observed a progressive...
We investigated synaptic communication and plasticity in hippocampal slices from mice overexpressing...
Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive ...
Degeneration of synaptic and axonal compartments of neurons is an early event contributing to the pa...
Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here...
Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here...
Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here...
The accumulation of cellular damage, including DNA damage, is hypothesized to contribute to aging-re...
The deleterious effects of aging on the brain remain to be fully elucidated. In the present study, p...
Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive ...
Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive ...
Age-related cognitive decline and neurodegenerative diseases are a growing challenge for our societi...
Aging is associated with a general decline in cognitive functions, which appears to be due to altera...
Cognitive decline is emblematic of brain aging, ascribed in large part to age-related changes occurr...
Thesis (M.A.)--Boston UniversityERCC1 is a DNA repair protein that forms a heterodimer with XPF. The...
Major histocompatibility complex class I (MHCI) proteins have been implicated in neuronal function t...
We investigated synaptic communication and plasticity in hippocampal slices from mice overexpressing...
Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive ...
Degeneration of synaptic and axonal compartments of neurons is an early event contributing to the pa...
Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here...
Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here...
Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here...
The accumulation of cellular damage, including DNA damage, is hypothesized to contribute to aging-re...
The deleterious effects of aging on the brain remain to be fully elucidated. In the present study, p...
Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive ...
Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive ...
Age-related cognitive decline and neurodegenerative diseases are a growing challenge for our societi...
Aging is associated with a general decline in cognitive functions, which appears to be due to altera...
Cognitive decline is emblematic of brain aging, ascribed in large part to age-related changes occurr...
Thesis (M.A.)--Boston UniversityERCC1 is a DNA repair protein that forms a heterodimer with XPF. The...
Major histocompatibility complex class I (MHCI) proteins have been implicated in neuronal function t...
We investigated synaptic communication and plasticity in hippocampal slices from mice overexpressing...
Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive ...
Degeneration of synaptic and axonal compartments of neurons is an early event contributing to the pa...