We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and was submitted to an allogeneic bonemarrow transplantation. Fifty-three days after the procedure, he died due to acute graft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in only five patients in the whole world, with three clinical presentations: myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloid ...
Abstract Background ABL1 gene translocations can be seen in precursor T-acute lymphoblastic leukemia...
Classification of myeloproliferative neoplasms is based on hematologic, histopathologic, and molecul...
Myeloid/lymphoid neoplasm is a rare malignancy with an aggressive course and rapid transformation to...
We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulti...
We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) result...
BCR-ABL1 negative myeloproliferative neoplasms (MPNs) are known to contain alterations of the tyrosi...
Copyright © 2015 A. N. Chamseddine et al. This is an open access article distributed under the Creat...
JAK2 V617F mutation and BCR-ABL translocation have been considered to be mutually exclusive. However...
We have identified a novel, recurrent t(8;9)(p21–22;p23–24) in six patients with diverse hematologic...
The presence of the translocation t(9;22)(q34;q11), leading to the BCR::ABL1 fusion transcript, is t...
Abstract Background Philadelphia (Ph) chromosome results from the reciprocal translocation t(9;22)(q...
Since very few Unusual BCR/ABL fusion transcripts in chronic myeloid leukemia have been reported, no...
A minority of chronic myeloid leukaemia (CML) patients express variant transcripts of which the e19a...
Atypical chronic myeloid leukemia, BCR-ABL1 negative (aCML) is a rare myelodysplastic syndrome (MDS)...
A case of chronic myeloid leukemia displaying an uncommon t(21;22)(q22;q11) is reported. For the fir...
Abstract Background ABL1 gene translocations can be seen in precursor T-acute lymphoblastic leukemia...
Classification of myeloproliferative neoplasms is based on hematologic, histopathologic, and molecul...
Myeloid/lymphoid neoplasm is a rare malignancy with an aggressive course and rapid transformation to...
We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulti...
We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) result...
BCR-ABL1 negative myeloproliferative neoplasms (MPNs) are known to contain alterations of the tyrosi...
Copyright © 2015 A. N. Chamseddine et al. This is an open access article distributed under the Creat...
JAK2 V617F mutation and BCR-ABL translocation have been considered to be mutually exclusive. However...
We have identified a novel, recurrent t(8;9)(p21–22;p23–24) in six patients with diverse hematologic...
The presence of the translocation t(9;22)(q34;q11), leading to the BCR::ABL1 fusion transcript, is t...
Abstract Background Philadelphia (Ph) chromosome results from the reciprocal translocation t(9;22)(q...
Since very few Unusual BCR/ABL fusion transcripts in chronic myeloid leukemia have been reported, no...
A minority of chronic myeloid leukaemia (CML) patients express variant transcripts of which the e19a...
Atypical chronic myeloid leukemia, BCR-ABL1 negative (aCML) is a rare myelodysplastic syndrome (MDS)...
A case of chronic myeloid leukemia displaying an uncommon t(21;22)(q22;q11) is reported. For the fir...
Abstract Background ABL1 gene translocations can be seen in precursor T-acute lymphoblastic leukemia...
Classification of myeloproliferative neoplasms is based on hematologic, histopathologic, and molecul...
Myeloid/lymphoid neoplasm is a rare malignancy with an aggressive course and rapid transformation to...