Role of Chronic Inflammation in Myopia Progression: Clinical Evidence and Experimental Validation
- Hui-Ju Lin
- Chang-Ching Wei
- Ching-Yao Chang
- Ter-Hsin Chen
- Yu-An Hsu
- Yi-Ching Hsieh
- Hsuan-Ju Chen
- Lei Wan
DOIAbstract
Prevention and treatment of myopia is an important public problem worldwide. We found a higher incidence of myopia among patients with inflammatory diseases such as type 1 diabetes mellitus (7.9%), uveitis (3.7%), or systemic lupus erythematosus (3.5%) compared to those without inflammatory diseases (p < 0.001) using data from children (<18 years old) in the National Health Insurance Research database. We then examined the inhibition of myopia by atropine in Syrian hamsters with monocular form deprivation (MFD), an experimental myopia model. We found atropine downregulated inflammation in MFD eyes. The expression levels of c-Fos, nuclear factor κB (NFκB), interleukin (IL)-6, and tumor necrosis factor (TNF)-α were upregulated in myopic eyes ...
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