The goal of this study was to develop a novel approach to the study and design of metamorphic mechanisms, based on a consideration of gene structure, mitosis, and cell fusion. In this study, we treat kinematic pairs as basic connection units that function similarly to the base pairs in DNA molecules and present expressions for the configuration of each kinematic pair in a mechanism. We also develop some methods to describe changes in the number of links, number of kinematic pairs, and pair features (type and configuration) during the folding process. Finally, we propose a method based on mitosis and cell fusion for studying the folding process and innovating mechanism design. In this method, a mechanism is first decomposed into some basic k...
"Joint-gene" concept is introduced as "changeable structural elements" in metamo...
Increasing evidences suggest that chromosome folding and genetic expression are intimately connected...
The variation among sequences and structures in nature is both determined by physical laws and by ev...
A methodology for synthesis and configuration design of metamorphic mechanisms is developed in this ...
Mitosis is a dynamic and stochastic process that has evolved to accurately segregate the genetic mat...
Current knowledge on the reaction whereby a protein acquires its native three-dimensional structure ...
AbstractMitotic chromosome structure and pathways of mitotic condensation remain unknown. The limite...
Much experimental work has been devoted in comparing the folding behavior of proteins sharing the sa...
Genetic and epigenetic inheritance through mitosis is critical for dividing cells to maintain their ...
Polypeptide chain has an invariant main-chain and a variant side-chain sequence. How the side-chain ...
The existing experimental data on protein folding is briefly reviewed. It is argued that the optima...
In vivo, the human genome folds into a characteristic ensemble of 3D structures. The mechanism drivi...
In preparation for mitotic cell division, the nuclear DNA of human cells is compacted into individua...
Condensation and faithful separation of the genome are crucial for the cellular life cycle. During c...
Microscopy and sequencing-based technologies are providing increasing insights into chromatin archit...
"Joint-gene" concept is introduced as "changeable structural elements" in metamo...
Increasing evidences suggest that chromosome folding and genetic expression are intimately connected...
The variation among sequences and structures in nature is both determined by physical laws and by ev...
A methodology for synthesis and configuration design of metamorphic mechanisms is developed in this ...
Mitosis is a dynamic and stochastic process that has evolved to accurately segregate the genetic mat...
Current knowledge on the reaction whereby a protein acquires its native three-dimensional structure ...
AbstractMitotic chromosome structure and pathways of mitotic condensation remain unknown. The limite...
Much experimental work has been devoted in comparing the folding behavior of proteins sharing the sa...
Genetic and epigenetic inheritance through mitosis is critical for dividing cells to maintain their ...
Polypeptide chain has an invariant main-chain and a variant side-chain sequence. How the side-chain ...
The existing experimental data on protein folding is briefly reviewed. It is argued that the optima...
In vivo, the human genome folds into a characteristic ensemble of 3D structures. The mechanism drivi...
In preparation for mitotic cell division, the nuclear DNA of human cells is compacted into individua...
Condensation and faithful separation of the genome are crucial for the cellular life cycle. During c...
Microscopy and sequencing-based technologies are providing increasing insights into chromatin archit...
"Joint-gene" concept is introduced as "changeable structural elements" in metamo...
Increasing evidences suggest that chromosome folding and genetic expression are intimately connected...
The variation among sequences and structures in nature is both determined by physical laws and by ev...