Objective: DNA methylation may be a stable epigenetic contributor to defining fat cell lineage. Methods: We performed reduced representation bisulfite sequencing (RRBS) and RNA-seq to depict a genome-wide integrative view of the DNA methylome and transcriptome during brown and white adipogenesis. Results: Our analysis demonstrated that DNA methylation is a stable epigenetic signature for brown and white cell lineage before, during, and after differentiation. We identified 31 genes whose promoters were significantly differentially methylated between white and brown adipogenesis at all three time points of differentiation. Among them, five genes belong to the Hox family; their expression levels were anti-correlated with promoter methylation, ...
The two types of thermogenic fat cells, beige and brown adipocytes, play a significant role in regul...
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of...
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of...
Objective: DNA methylation may be a stable epigenetic contributor to defining fat cell lineage. Met...
Aim: To define the genomic distribution and function of DNA methylation changes during human adipoge...
Insight into the processes controlling adipogenesis is important in the battle against the obesity e...
Body fat distribution plays an important role in determining metabolic health. Whereas central obesi...
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic i...
Objective/methods: DNA methylation plays an important role in obesity and related metabolic complica...
Adipose tissue is not homogenous as individual fat depots display regional variation in their physio...
Body fat distribution plays an important role in determining metabolic health. Whereas central obesi...
Genome-wide DNA methylation profiling was performed of human mesenchymal stem cells (hMSCs) differen...
Park et al. shed light on the dynamics of DNA demethylation during adipocyte differentiation, which ...
Epigenetic regulation, including DNA methylation, plays an important role in several differentiation...
The two types of thermogenic fat cells, beige and brown adipocytes, play a significant role in regul...
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of...
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of...
Objective: DNA methylation may be a stable epigenetic contributor to defining fat cell lineage. Met...
Aim: To define the genomic distribution and function of DNA methylation changes during human adipoge...
Insight into the processes controlling adipogenesis is important in the battle against the obesity e...
Body fat distribution plays an important role in determining metabolic health. Whereas central obesi...
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic i...
Objective/methods: DNA methylation plays an important role in obesity and related metabolic complica...
Adipose tissue is not homogenous as individual fat depots display regional variation in their physio...
Body fat distribution plays an important role in determining metabolic health. Whereas central obesi...
Genome-wide DNA methylation profiling was performed of human mesenchymal stem cells (hMSCs) differen...
Park et al. shed light on the dynamics of DNA demethylation during adipocyte differentiation, which ...
Epigenetic regulation, including DNA methylation, plays an important role in several differentiation...
The two types of thermogenic fat cells, beige and brown adipocytes, play a significant role in regul...
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of...
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of...