Objective: To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells (MCF-7/Dox) in cytotoxicity apoptosis and P-glycoprotein (Pgp) expression in combination with doxorubicin. Methods: The cytotoxic properties, 50% inhibition concentration (IC50) and its combination with doxorubicin in MCF-7 cell lines resistant to doxorubicin (MCF-7/Dox) cells were determined using MTT assay. Apoptosis induction was examined by double staining assay using ethidium bromide-acridine orange. Immunocytochemistry assay was performed to determine the level and localization of Pgp. Results: Single treatment of hesperidin showed cytotoxic activity on MCF-7/Dox cells with IC50 value of 11 μmol/L. Thus, combination treatmen...
Context: It has been shown that hesperidin induces apoptosis in NALM-6 cells through inhibition of n...
Long-term use of doxorubicin cause cancer resistance due to overexpression of P-glycoprotein (Pgp), ...
Breast cancer (BC) has high incidence and mortality rates, making it a major global health issue. BC...
ABSTRACTObjectiveTo evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant ...
Hesperidin, a flavonoid, shows strong cytotoxic effect in several cancer cell lines. The aim of this...
Hesperidin, a flavonoid, shows strong cytotoxic effect in several cancer cell lines. The ...
Doxorubicin is a chemotherapeutic agent used to treat breast cancer, but it induces resistance in so...
Combination of chemotherapeutic agent and chemopreventive agent is being a new approach in cancer tr...
Long-term use of doxorubicin causes cancer resistance due to overexpression of P-glycoprotein (P-gp)...
Hesperidin is a flavonoid commonly found in citrus fruits. Studies have shown that hesperidin has an...
Long-term use of doxorubicin causes cancer resistance due to overexpression of P-glycoprotein (P-gp...
Hesperidin, senyawa flavonoid menunjukkan efek toksik pada beberapa sel kanker. Tujuan penelitian In...
Therapy of colon cancer by using 5-FU often causes problems of resistance. This encourages the devel...
Combination of chemotherapeutic agent and chemopreventive agent is being a new approach in cancer tr...
Doxorubicin as the common drug for breast cancer has been widely proposed to use in combine with a n...
Context: It has been shown that hesperidin induces apoptosis in NALM-6 cells through inhibition of n...
Long-term use of doxorubicin cause cancer resistance due to overexpression of P-glycoprotein (Pgp), ...
Breast cancer (BC) has high incidence and mortality rates, making it a major global health issue. BC...
ABSTRACTObjectiveTo evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant ...
Hesperidin, a flavonoid, shows strong cytotoxic effect in several cancer cell lines. The aim of this...
Hesperidin, a flavonoid, shows strong cytotoxic effect in several cancer cell lines. The ...
Doxorubicin is a chemotherapeutic agent used to treat breast cancer, but it induces resistance in so...
Combination of chemotherapeutic agent and chemopreventive agent is being a new approach in cancer tr...
Long-term use of doxorubicin causes cancer resistance due to overexpression of P-glycoprotein (P-gp)...
Hesperidin is a flavonoid commonly found in citrus fruits. Studies have shown that hesperidin has an...
Long-term use of doxorubicin causes cancer resistance due to overexpression of P-glycoprotein (P-gp...
Hesperidin, senyawa flavonoid menunjukkan efek toksik pada beberapa sel kanker. Tujuan penelitian In...
Therapy of colon cancer by using 5-FU often causes problems of resistance. This encourages the devel...
Combination of chemotherapeutic agent and chemopreventive agent is being a new approach in cancer tr...
Doxorubicin as the common drug for breast cancer has been widely proposed to use in combine with a n...
Context: It has been shown that hesperidin induces apoptosis in NALM-6 cells through inhibition of n...
Long-term use of doxorubicin cause cancer resistance due to overexpression of P-glycoprotein (Pgp), ...
Breast cancer (BC) has high incidence and mortality rates, making it a major global health issue. BC...