Association between the biochemical profiles in blood and bone mineral density in Chinese Han population: findings from a cross-sectional study

Hong-Xia Chen,1,2,* Li-Bing Wu,3,* Zhong-Ji Meng1 1Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, People’s Republic of China; 2Department of Environmental, Agricultural, & Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA; 3Department of Nuclear Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, People’s Republic of China *These authors contributed equally to this work. Abstract: This study investigated the possible correlation between blood biochemical profiles and bone mineral density (BMD) in the Chinese Han population. We conducted a cross-sectional analysis using participants randomly selected from the Health Screening Center of Taihe Hospital, Hubei University of Medicine, which included a total of 285 individuals, varied in ages from 31 years to 63 years. The height, weight, and body mass index (BMI) of each subject were measured, as well as fasting blood glucose (FBG), triglycerides, total cholesterol, blood uric acid (UA), blood urea nitrogen, and blood creatinine. We evaluated BMD at the wrist (grams per centimeter square) using a dual-energy X-ray absorptiometry scan. The mean ages of female and male groups were 45.32±8.24 years and 46.76±9.01 years, respectively. The mean age of the study population was 46.14±8.79 years, which is similar to the general population. The mean BMI values were 22.08±2.38 kg/m2 and 24.50±2.67 kg/m2 in the female and male population, respectively, representing a statistically significant difference (P<0.05). No significant differences in levels of FBG total cholesterol, or triglycerides were seen among the male and female population. Multiple linear regression analysis was performed using BMD as outcome variables and BMI, blood UA, FBG, total cholesterol, triglycerides, urea nitrogen, and blood creatinine as covariates, and the regression equation was established as Y=0.00017X1+0.001066X2+0.010017X3+0.168251. Positive correlation was identified between BMD and FBG and BMI and blood UA, suggesting that lipid metabolism imbalance might have neither positive nor negative effect on BMD. There might be an association between UA and BMD (P<0.05). In conclusion, these findings suggested that weak positive correlations existed between BMI and FBG and blood UA and BMD in this middle-aged Chinese Han population. Keywords: bone mass density, body mass index, blood uric acid, Chinese Han populatio