Endothelial dysfunction of vessels at ANCA-associated systemic vasculitis

Aim. To evaluate clinical-pathogenetic relationship between systemic vasculitis associated with anti-neutrophil cytoplasmic antibodies and vascular endothelial dysfunction. Materials and methods. In order to clarify relationships between clinical course of systemic vasculitis with the state of the endothelial vascular function the indicators of endothelial function of vessels in blood (the levels of endothelin-1, thromboxane A2, homocysteine, prostacyclins, nitrites, cyclic guanosine monophosphate) were studied with biochemical and immunoenzyme methods in 129 patients (76 - with microscopic polyangiitis, 26 – with Wegener's granulomatous polyangiitis and 27 - with eosinophilic polyangiitis Churg-Strauss). Results. The imbalance of levels of vasoconstrictors and vasodilators was determined. It was manifested by increased concentrations of endothelin-1 and nitrites in the background of the the amount of prostacyclin and homocysteine reduce. Conclusions. The abnormality of endothelial dysfunction of vessels in systemic vasculitis were involved in the vasculitis pathogenesis