Left Ventricular Functions and Its Relation with Grade of Hepatosteatosis in Non-Alcholic Fatty Liver Disease

INTRODUCTION: This study was designed to asses left ventricular functions and its relation with hepatosteatosis grade with conventional and tissue Doppler echocardiography in patients with the non-alcholic fatty liver disease.\ud METHODS: A total of 32 patients (15 males, 17 females; mean age 50±9 years and) with ultrasonographically diagnosed non-alcholic fatty liver disease and 22 healty subjects ( 11 female and 11 male; mean age: 50±10) without hepatosteatosis were enrolled in this study. Left ventricular systolic and diastolic functions, myocardial performance index and its relation with HS grade were assessed by conventional and tissue Doppler echocardiography.\ud RESULTS: There were no statistically significant charasteristics difference, chambers diameters, standard Doppler parameters and conventional echocardiography parameters between the patients and control groups. Among tissue Doppler parameters the mitral annulus peak early diastolic velocity and ratio of early to late diastolic velocity were lower in patients group than in controls ( p < 0.001, p < 0.001 respectively). Isovolumetric relaxation time (IVRT) and myocardial performance index (MPI) were significantly higher ( p = 0.002, p < 0.001 respectively) in the patient group. There were no significant differences in mitral annuler late diastolic velocity, deceleration time of early diastolic filling, mitral annuler peak systolic velocity, isovolumetric contraction time and contraction time between the two groups. HS grade was positively correlated with the left ventricle MPI index ( r = 0.57 p = 0.001).\ud DISCUSSION AND CONCLUSION: These results show that left ventricular diastolic dysfunctions in patients with non-alcholic fatty liver disease and degree of hepatosteatosis is associated with left ventricular diastolic dysfunctions