The role of FGF23 as an early marker of chronic renal failure

Chronic renal failure is a growing problem worldwide and it is particularly important to note that this is irreversible and progressive illness with many complications. That is why it is necessary early to be diagnosed and, as soon as possible, adequately treated. Clinical studies have shown a correlation between fibroblast growth factor 23 (FGF23) and cardiovascular risk factors, left ventricular hypertrophy and vascular calcification. Therefore, FGF23 gives the possibility for the evaluation of new therapeutic modalities in order to improve survival of patients with chronic renal disease. Further studies are needed to clarify the precise mechanism of action and regulation of FGF23 under normal circumstances and as part of chronic renal failure