THE ROLE OF PHOSPHORUS, PTH, FGF-23, KLOTHO AND VITAMIN D ON HEMOGLOBIN LEVELS OF PATIENTS WITH CKD

RUSSO, LUIGI
BRUZZESE, DARIO
RUSSO, DOMENICO
Battaglia, Yuri
Iorio, Biagio Di
Lullo, Luca Di
Minutolo, Roberto
Morrone, Luigi

Publication date

January 2016

Abstract

Introduction and Aims: Parathyroid hormone (PTH) is strong predictor of low levels of hemoglobin (Hb) in dialysis patients with severe hyperparathyroidism. Inverse association between PTH and Hb exists in non-dialysis CKD-patients and a doubled risk of Hb <10.0 mg/dL in absence of severely deranged PTH concentration. Higher phosphorus (P) levels associated with a greater likelihood for anemia both in early CKD-stages patients and in subjects with normal kidney function suggesting that P may be a biomarker of anemia. FGF-23 may play a role in the mechanisms leading to anemia through its interplay with serum P, vitamin D and suppression of Klotho. Low Klotho levels associated with senescence, cell toxicity, premature aging, vascular calcifica...

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THE ROLE OF PHOSPHORUS, PTH, FGF-23, KLOTHO AND VITAMIN D ON HEMOGLOBIN LEVELS OF PATIENTS WITH CKD

Abstract

Extracted data

THE ROLE OF PHOSPHORUS, PTH, FGF-23, KLOTHO AND VITAMIN D ON HEMOGLOBIN LEVELS OF PATIENTS WITH CKD

Abstract

Extracted data

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