A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma
- D'ARRIGO, PAOLO
- RUSSO, MICHELE
- Rea, Anna
- Tufano, Martina
- GUADAGNO, ELIA
- DEL BASSO DE CARO, MARIALAURA
- PACELLI, ROBERTO
- Hausch, Felix
- STAIBANO, STEFANIA
- ILARDI, GENNARO
- PARISI, SILVIA
- ROMANO, MARIA FIAMMETTA
- ROMANO, SIMONA
DOIAbstract
FKBP51 is a co-chaperone with isomerase activity, abundantly expressed in glioma. We previously identified a spliced isoform (FKBP51s) and highlighted a role for this protein in the upregulation of Programmed Death Ligand 1 (PD-L1) expression in melanoma. Because gliomas can express PD-L1 causing a defective host anti-tumoral immunity, we investigated whether FKBP51s was expressed in glioma and played a role in PD-L1 regulation in this tumour
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