K-ras gene mutations (codons 12 and 13) were determined by PCR-based mutant allele-specific amplification (MASA) in tumour tissue of 185 colon cancer patients: 36␑arboured mutations, of which 82 ere located in codon 12. High intakes of animal protein, calcium and poultry were differently associated with codon 12 and 13 mutations: odds ratios (OR) and 95␌onfidence intervals (95␌I) for codon 12 versus codon 13 were 9.0 (2.0–42), 4.1 (1.4–12) and 15 (1.4–160), respectively. In case–control comparisons, high intakes of animal protein and calcium were positively associated with colon tumours harbouring codon 12 mutations [for animal protein per 17 g, OR (95␌I) = 1.5 (1.0–2.1); for calcium per 459 mg, 1.2 (0.9–1.6)], while inverse associations we...
Oncogenic mutations of Ras at codons 12, 13, or 61, that render the protein constitutively active, a...
Point mutations of the K-RAS gene at codon 12 are found in about 40\% of cases with colorectal cance...
Inactivating mutations in APC are thought to be early, initiating events in colorectal carcinogenesi...
K-ras gene mutations (codons 12 and 13) were determined by PCR-based mutant allele-specific amplific...
Background: K-ras mutations, one of the earliest events observed in colorectal carcinogenesis, are m...
K-ras mutation-positive (K-ras+) and -negative (K-ras-) colorectal adenomas may differ clinically an...
K-ras mutation-positive (K-ras+) and -negative (K-ras-) colorectal adenomas may differ clinically an...
K-ras mutation-positive (K-ras+) and -negative (K-ras-) colorectal adenomas may differ clinically an...
Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 4...
Epidemiologic data support an association between diet and mutations in the Kirsten-ras (KRAS) gene ...
The interactions between environmental factors and the genetic and epigenetic changes that drive col...
Oncogenic mutations of Ras at codons 12, 13, or 61, that render the protein constitutively active, a...
Item does not contain fulltextThe interactions between environmental factors and the genetic and epi...
Oncogenic mutations of Ras at codons 12, 13, or 61, that render the protein constitutively active, a...
Point mutations of the K-RAS gene at codon 12 are found in about 40\% of cases with colorectal cance...
Inactivating mutations in APC are thought to be early, initiating events in colorectal carcinogenesi...
K-ras gene mutations (codons 12 and 13) were determined by PCR-based mutant allele-specific amplific...
Background: K-ras mutations, one of the earliest events observed in colorectal carcinogenesis, are m...
K-ras mutation-positive (K-ras+) and -negative (K-ras-) colorectal adenomas may differ clinically an...
K-ras mutation-positive (K-ras+) and -negative (K-ras-) colorectal adenomas may differ clinically an...
K-ras mutation-positive (K-ras+) and -negative (K-ras-) colorectal adenomas may differ clinically an...
Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 4...
Epidemiologic data support an association between diet and mutations in the Kirsten-ras (KRAS) gene ...
The interactions between environmental factors and the genetic and epigenetic changes that drive col...
Oncogenic mutations of Ras at codons 12, 13, or 61, that render the protein constitutively active, a...
Item does not contain fulltextThe interactions between environmental factors and the genetic and epi...
Oncogenic mutations of Ras at codons 12, 13, or 61, that render the protein constitutively active, a...
Point mutations of the K-RAS gene at codon 12 are found in about 40\% of cases with colorectal cance...
Inactivating mutations in APC are thought to be early, initiating events in colorectal carcinogenesi...
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