Irinotecan is a well-known chemotherapy drug for the treatment of various cancers. However, delayed-onset diarrhea is a common adverse reaction, limiting the application of the drug. The study presented was designed to evaluate the preventive effects of Shengjiang Xiexin decoction (SXD) on irinotecan-induced diarrhea and to explore the possible mechanisms of this action. We established a diarrhea rat model. The condition of the rats was observed. The proliferation and apoptosis of intestinal cells were measured using immunohistochemical assays and a caspase-3 activity assay, respectively. The expression of Lgr5 and CD44 staining were used to observe intestinal stem cells (ISCs). In addition, the activity of β-glucuronidase in the rats’ fece...
Qingchang Wenzhong Decoction (QCWZD) is an effective traditional Chinese medicine prescription. Our ...
© 2008 Landes BioscienceOBJECTIVES: Chemotherapy-induced diarrhea (CID) is a well recognized side ef...
Xilei san (XLS), a herbal preparation widely used in China for erosive and ulcerative diseases, has ...
Shengjiang Xiexin decoction (SXD), a classic traditional Chinese medical formula chronicled in Shang...
Irinotecan (CPT-11) is used for therapy of various cancers. However, it has several serious adverse ...
Background: Irinotecan (CPT-11) can be used as a first-line therapeutic drug against extensive-stage...
To investigate the effect and mechanism of QingHuaZhiXie prescription on diarrhea predominant irrita...
Stress diarrhea is a major challenge for weaned piglets and restricts pig production efficiency and ...
Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in particular for d...
Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in particular for d...
Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in particular for d...
Context Jian Pi Qing Chang Hua Shi decoction (JPQCHSD) has been considered as an effective remedy fo...
Chemotherapy-induced diarrhoea is a major oncological problem, caused by the cytotoxic effects of ca...
Statement of the Problem: Irinotecan is used as a single agent or in combination with other drugs to...
PURPOSE: Delayed diarrhea is the most important side effect of irinotecan. The aim of this study was...
Qingchang Wenzhong Decoction (QCWZD) is an effective traditional Chinese medicine prescription. Our ...
© 2008 Landes BioscienceOBJECTIVES: Chemotherapy-induced diarrhea (CID) is a well recognized side ef...
Xilei san (XLS), a herbal preparation widely used in China for erosive and ulcerative diseases, has ...
Shengjiang Xiexin decoction (SXD), a classic traditional Chinese medical formula chronicled in Shang...
Irinotecan (CPT-11) is used for therapy of various cancers. However, it has several serious adverse ...
Background: Irinotecan (CPT-11) can be used as a first-line therapeutic drug against extensive-stage...
To investigate the effect and mechanism of QingHuaZhiXie prescription on diarrhea predominant irrita...
Stress diarrhea is a major challenge for weaned piglets and restricts pig production efficiency and ...
Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in particular for d...
Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in particular for d...
Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in particular for d...
Context Jian Pi Qing Chang Hua Shi decoction (JPQCHSD) has been considered as an effective remedy fo...
Chemotherapy-induced diarrhoea is a major oncological problem, caused by the cytotoxic effects of ca...
Statement of the Problem: Irinotecan is used as a single agent or in combination with other drugs to...
PURPOSE: Delayed diarrhea is the most important side effect of irinotecan. The aim of this study was...
Qingchang Wenzhong Decoction (QCWZD) is an effective traditional Chinese medicine prescription. Our ...
© 2008 Landes BioscienceOBJECTIVES: Chemotherapy-induced diarrhea (CID) is a well recognized side ef...
Xilei san (XLS), a herbal preparation widely used in China for erosive and ulcerative diseases, has ...