Synthesis and antitubercular evaluation of 7-chloro-4-alkoxyquinoline derivatives

<p>A series of eight 7-chloro-4-alkoxyquinoline derivatives (<strong>2a-h</strong>) have been synthesized and their <em>in vitro </em>(antimycobacterial) activity against <em>Mycobacterium tuberculosis </em>was evaluated. <em> </em>Furthermore, all the active compounds were selected for evaluation of their cytotoxicities against the human hepatoma (HepG2) and the relative selectivity (selective index) of these compounds against <em>M. tuberculosis</em> compared to HepG2 was calculated based on MLD₅₀/MIC ratios. These biological results have been compared to a series of 7-chloro-4-aminoquinoline derivatives <strong>1a-i</strong>, previously identified by our research group with the aim to provide important information about the structure-activity relationship of quinoline derivatives.