L-Glutamate Profile in Acute Ischemic Stroke After Intra Arterial Heparin Flushing

<p><strong><span lang="EN-US">Objective:</span></strong><span lang="EN-US">The intra arterial heparin flushing ( IAHF ) is one of the endovascular procedure that in facts have benefit effect to improving the motoric function after acute ischemic stroke, but the exact mechanism not yet known clearly. The L-glutamate is a neurotransmitter that have important role in the brain metabolism. How the profile of L-glutamate after IAHF not yet published. The purpose of this study is to know how the IAHF affect the Glutamate concentration in the blood and muscle function which measured by Manual Muscle Testing-Medical Research Councils (MMT-MRC) in Acute Ischemic Stroke Patients.</span></p><p><strong><span lang="EN-US">Method:</span></strong><span lang="EN-US"> The thirty nine patients of acute ischemic stroke that admitted to hospital, was studied of L-Glutamate serum profile. The patients grouping depend on onset ( &lt;7 days, 7-14 days after stroke onset ), site of infarction ( cortical and subcortical ), and size of infarction ( lacunar and wide infarct ). The outcome of motoric function was recorded and measured by MRCs ( Motoric Research Council Scale ; 0-5 ) in the arm weakness, MRCs &lt; 18 ; severe, 18-23; moderate, 24-29; mild ). The L-glutamate serum level measured before and after IAHF.</span></p><p><strong><span lang="EN-US">Results:</span></strong><em><span lang="EN-US">Characteristic of sample</span></em><span lang="EN-US"> = <em>Onset</em> : <em>&lt;7 days</em> = Before : 19,51±6,74. After : 20,64±7,45. P = 0,474. <em>7-14 days</em> =Before : 18,70±6,08, After :22,70±7,72, p=0,046.<em>Site of infarction</em>; cortical = Before : 21,63±9,55, After : 25,94±8,22.P = 0,098; Subcortical = Before : 18,32±4,3,after : 19,69±6,58. p = 0,370. <em>Size of infarct</em> : Lacunar = before : 18,32±4,3.After : 19,69±6,48. p= 0,370. Non-Lacunar = Before : 21,63±9,55. After : 25,94±8,22, p = 0,098. <em>Muscle Strength : </em>MRCs &lt; 18 = before : 16,68±5,13, after : 19,67±5,72, p= 0,060. MRCs (Upper Arms) 18-23; Before : 24,70±4,72, After : 27,95±6,93, p = 0,372. MRCs 24-29; Before : 18,17±6,93 After : 20,53±7,89, p = 0,248.</span></p><p><strong><span lang="EN-US">Conclusion:</span></strong><span lang="EN-US">The L-glutamate serum level was increasing after IAHF, but not significantly different according to the all of group in this study.</span></p><p><strong><span lang="EN-US">Keywords:</span></strong><em><span lang="EN-US">L-glutamate, acute ischemic stroke, IAHF, muscle strength</span></em>