FAKTOR LINGKUNGAN YANG DAPAT MENINGKATKAN RISIKO PENYAKIT LUPUS ERITEMATOSUS SISTEMIK

<p>The Risk of Lupus Erythematosus Systemic Disease caused by Enviromental Factor.</p><p>The cause of Lupus Erythematosus Systemic (LES) disease has not yet found, however, experts said that environment factor is considered to be dominant cause. It might increase the risk of LES. Environmental factor consists of physics, biology and chemical. Moreover, there are also stress, herediter and hormonne factors. This study used a cross sectional design with two hospital as a population target. They are Cipto Mangunkusumo and Kramat 128 hospital in which patients of LES included in Indonesian Lupus Foundation. Structural interview was used in this research to know the LES patients history before they experienced LES. From 202 LES patients, the research results showed percentage of patient exposed with direct sunlight (22.2%), ISPA (58.9%), drugs such as ampisilin/amoksisilin (63.1%), passive smoker (81.7%), active smoker (11.9%), fertility woman with age 15-44 years (88.4%), used contraception/tablet (91.0%), herediter (1.5%) and stress (85.6%). In summary, physical factor, for instance, time frequently exposed by direct sunlight, used drugs, nicotine, infected by bacteria, mush room and or virus could risk LES disease. The risk of LES happens also for patients who used contraception such as tablet/injection and woman in fertility age group.</p><p>Keywords: LES, environmental factor, hormone, stress