DEKOK DAUN PALIASA (KLEINHOVIA HOSPITA LINN) SEBAGAI OBAT RADANG HATI AKUT

<p>Paliasa leaves (Kleinhovia hospita Linn) are traditionally used as a treatment for hepatitis, but noscientific information about this medicine has been reported. The aim of this study is to examine the benefit of paliasa leaves for treatment of hepatitis using rats with the disease as an experimental model. This study used 63 6-month old female rats Wistar strain with an average weight of 150,28 gr ± 4,45 gr. This study utilised a complete random design method, consisting of 7 treatments with 9 repeats. The negative control (NC) group received distilled water, while the positive control (PC) group received carbon tetrachloride (CCI4) in solution. The experimental groups received either paliasa leaves extract at a dose of 250 mg/kg of body weight (PI), a dose of 500 mg/kg of body weight (P2), a dose of 750 mg/kg of body weight (P3), adose of 1000 mg/kg of body weight (P4), or a dose of 1250 mg/kg of body weight (P5). The parameters examined were SGPT, lipid peroxide and damage to liver cells. Prior to receiving the assigned doses, all experimental groups and the positive control group received 0.05 mg/kg of body weight of CCI4 in solution to damage the liver function, while the negative control group only received distilled water. Following that, the assigned doses were administered orally using 1ml gauge at 24 and 48 hours. After 50 hours, all rats were culled by ether treatment, cardiac bled, and liver removed. The results suggested that there was asignificant difference between the positive control group and the experimental groups (P&lt; 0.05), although no significant differences were observed between the different doses given. It can be concluded that paliasa leaves extract can be used for treatment of hepatitis caused by exposure to CCI4 in experimental rats at adose as low as 250 mg/kg of body weight. Paliasa leaves contain Saponin, Cardenolin and Antrakinon, butwhich component act to protect the liver from hepatitis remains to be elucidated.</p><p> </p><p>Keywords: Hepatitis, Paliasa leaves, rats, CCI4