Dimethylarginines, blood glucose, and C-reactive protein in patients with acute myocardial infarction
- Aurélie Gudjoncik
- Marianne Zeller
- Julie Lorin
- Eve Rigal
- Yves Cottin
- Catherine Vergely
- Luc Rochette
DOIAbstract
Background: Asymmetric dimethylarginine (ADMA), and its symmetrical stereoisomer (SDMA) — as methylated products of l-arginine, decrease nitric oxide (NO) availability. Their elevated levels in diabetes increase the risk of acute myocardial infarction (MI), through endothelial dysfunction. Aims: We investigated the relationship between circulating levels of ADMA, SDMA and functional relevant parameters in patients with acute MI. Methods: Prospective study from 31 MI patients hospitalized <12 h after symptom onset. Blood samples were taken on admission and serum levels of ADMA, SDMA and l-arginine were determined using high-performance liquid chromatography (HPLC). Results: Mean age was 65y, most were male, hypertensive, 1/3rd were current s...
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