The effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: a human intervention study
- Beulens, J.W.J.
- Loon, van, L.J.C.
- Kok, F.J.
- Pelsers, M.
- Bobbert, T.
- Spranger, J.
- Helander, A.
- Hendriks, H.F.J.
DOIAbstract
Aims/hypothesis The aim of this study was to investigate whether moderate alcohol consumption increases plasma high molecular weight (HMW) adiponectin and/or muscle oxidative capacity. Materials and methods Eleven lean (BMI 18 - 25 kg/m(2)) and eight overweight ( BMI >= 27 kg/m(2)) men consumed 100 ml whisky (similar to 32 g alcohol) or water daily for 4 weeks in a randomised, controlled, crossover trial. After each treatment period, muscle biopsies and fasting blood samples were collected. Results Adiponectin concentrations increased ( p <0.001) by 12.5% after 4 weeks of moderate alcohol consumption. Moderate alcohol consumption tended to increase HMW adiponectin by 57% ( p= 0.07) and medium molecular weight adiponectin by 12.5% ( p= 0.07)...
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