A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Extensively Studied by Flow Cytometry and Immunohistochemistry
- Martina Pennisi
- Clara Cesana
- Micol Giulia Cittone
- Laura Bandiera
- Barbara Scarpati
- Valentina Mancini
- Silvia Soriani
- Silvio Veronese
- Mauro Truini
- Silvano Rossini
- Roberto Cairoli
Publication date
January 2017
DOI Publisher
Hindawi Limited ISSN
2090-6560 Journal
issn:2090-6560Abstract
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with aggressive clinical course and poor prognosis. Diagnosis is based on detection of CD4+ CD56+, CD123high, TCL-1+, and blood dendritic cell antigen-2/CD303+ blasts, together with the absence of lineage specific antigens on tumour cells. In this report we present a case of BPDCN presenting with extramedullary and bone marrow involvement, extensively studied by flow cytometry and immunohistochemistry, who achieved complete remission after acute lymphoblastic leukemia like chemotherapy and allogeneic hematopoietic stem cell transplantation
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