Jumlah sel makrofag gingiva tikus wistar jantan yang diinduksi periodontitis setelah pemberian ekstrak etanolik kulit manggis Amount of machropahges cells in periodontitis-induced wistar rats after mangosteen rind etanolic extract administration

Periodontitis is characterized with macrophages infiltration that is used to fagocyt bacteria which infiltrated at gingiva. Mangosteen rind contains xantone, an anti-inflammatory substance which inhibits the synthesis of PGE2 and therefore reduce inflammatory cells infiltration. This research aimed to study machropahges cells infiltration in periodontitis-induced wistar rats after administration of mangosteen rind etanolic extract. Forty eight male wistar rats were induced periodontitis for 7 days. After the ligation was taken out, the rats were divided into 4 groups, and treated orally with mangosteen rind extract 60 mg/kg BB, 30 mg/kg BB, ibuprofen and saline. The rats were sacrified on the 1st, 3rd, 4th, and 7th day after the treatment. Their anterior lower jaws were processed histologically and stained with hematoxylin eosin. Two-way anova test showed a significant difference among groups (p