Plasma Uric Acid is Associated with Postinfarction Cardiac Remodeling in Elderly with Old Myocardial Infarction

Background: The increased plasma uric acid has been documented in ischemic cardiomyopathy (ICM) and heart failure in other age ranges in human and in animal models. However, it remains incompletely clear whether plasma uric acid is associated with cardiac remodeling, ischemic cardiomyopathy and heart failure in elderly. So, the objective of the study was to investigate whether plasma uric acid was associated with postinfarction cardiac remodeling in elderly with a previous myocardial infarction. Methods: Data of 246 elderly aged 60 years and older with angiography-confirmed coronary heart disease and myocardial infarction were analyzed. Among the patients, 89 had ICM defined as left ventricular end-diastolic diameter [men > 55 mm, women > 50 mm (60.74±5.79 mm)] measured by echocardiography. Difference in plasma uric acid was analyzed between patients with and without ICM. Results: There was significant increase in plasma uric acid in ICM compared with non-ICM (444.66±160.97 umol/L vs. 372.59±131.31 umol/L, p=0.000), and plasma uric acid was significantly positively related to left ventricular end-diastolic diameter (r=0.312, p=0.000). Conclusions: Plasma uric acid is significantly increased in elderly with ICM complicated with previous myocardial infarction as well as with those elderly patients who have postinfarction cardiac remodeling and previous myocardial infarction