Studies of breast cancer stem cells are in their infancy and many fundamental questions have yet to be fully addressed. The molecular distinction between normal and cancerous breast stem cells is not clear. While there have been recent breakthroughs in mouse mammary stem cells and lineage determination in mammary glands, little has been determined in human cells. Microarray analyses have provided molecular categorization of breast cancer. However, the cellular origin of different types of breast cancer is largely unknown. In addition, the relationship between breast cancer stem cells and mammary progenitor cells has yet to be clarified. One of the key questions is how a normal mammary stem cell becomes a breast cancer stem cell. Importantly...
The origins of the epithelial cells participating in the development, tissue homeostasis, and cancer...
Two different hypotheses about cell of origin of breast cancer have been proposed. One theory states...
Emerging evidence suggests that cancers arise in stem/progenitor cells. Yet, the requirements for tr...
Studies of breast cancer stem cells are in their infancy and many fundamental questions have yet to ...
Breast cancer is the most common incident form of cancer in women including different subtypes. Canc...
Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecula...
Cancer arises from subpopulations of transformed cells with high tumor initiation and repopulation a...
Cancer arises from subpopulations of transformed cells with high tumor initiation and repopulation a...
13 páginas, 2 figuras.There are increasing data supporting the existence of a cell hierarchy within ...
SummaryPathways that govern stem cell (SC) function are often subverted in cancer. Here, we report t...
The cancer stem cell theory poses that cancers develop from a subset of malignant cells that possess...
Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isol...
The mammary gland undergoes major developmental changes during puberty and pregnancy. It is thought ...
IntroductionThe diversity of human breast cancer subtypes has led to the hypothesis that breast canc...
Breast cancer tumors display different cellular phenotypes. A growing body of evidence points toward...
The origins of the epithelial cells participating in the development, tissue homeostasis, and cancer...
Two different hypotheses about cell of origin of breast cancer have been proposed. One theory states...
Emerging evidence suggests that cancers arise in stem/progenitor cells. Yet, the requirements for tr...
Studies of breast cancer stem cells are in their infancy and many fundamental questions have yet to ...
Breast cancer is the most common incident form of cancer in women including different subtypes. Canc...
Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecula...
Cancer arises from subpopulations of transformed cells with high tumor initiation and repopulation a...
Cancer arises from subpopulations of transformed cells with high tumor initiation and repopulation a...
13 páginas, 2 figuras.There are increasing data supporting the existence of a cell hierarchy within ...
SummaryPathways that govern stem cell (SC) function are often subverted in cancer. Here, we report t...
The cancer stem cell theory poses that cancers develop from a subset of malignant cells that possess...
Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isol...
The mammary gland undergoes major developmental changes during puberty and pregnancy. It is thought ...
IntroductionThe diversity of human breast cancer subtypes has led to the hypothesis that breast canc...
Breast cancer tumors display different cellular phenotypes. A growing body of evidence points toward...
The origins of the epithelial cells participating in the development, tissue homeostasis, and cancer...
Two different hypotheses about cell of origin of breast cancer have been proposed. One theory states...
Emerging evidence suggests that cancers arise in stem/progenitor cells. Yet, the requirements for tr...