Integrated Assessment (IA) models aim at providing information- and decision-support to complex problems. This paper argues that uncertainty analysis in IA models should be user-driven in order to strengthen science–policy interaction. We suggest an approach to uncertainty analysis that starts with investigating model users’ demands for uncertainty information. These demands are called “uncertainty information needs”. Identifying model users’ uncertainty information needs allows focusing the analysis on those uncertainties which users consider relevant and meaningful. As an illustrative example, we discuss the case of examining users’ uncertainty information needs in the SEAMLESS Integrated Framework (SEAMLESS-IF), an IA model chain for ass...