Intracerebral Hemorrhage Due to Intravenous Thrombolytic Treatment in Acute Ischemic Stroke

INTRODUCTION: Acute ischemic stroke is an emergency which can be treated by intravenous thrombolytic treatment in the first 4.5 hours. The most important complication effecting prognosis of intravenous thrombolysis is the symptomatic intracerebral hemorrhage. The aim of our study is to determine the risk factors of intracerebral hemorrhage due to intravenous thrombolytic treatment. METHODS: In our study, 12 patients with intracerebral hemorrhage due to intravenous thrombolytic therapy hospitalized in Neurological Intensive Care Unit between 2009-2014 were revised retrospectively. RESULTS: Twelve patients who had intracerebral hemorrhage due to thrombolytic treatment were included. Nine of the cases (75.0%) had asymptomatic intracerebral hemorrhage, whilst 3 (% 25.0) had symptomatic intracerebral hemorrhage. DISCUSSION AND CONCLUSION: There were many studies aiming to put forth the risk of intracerebral hemorrhage associated with intravenous thrombolytic therapy. Advanced age, body weight > 95 kg, the history of diabetes mellitus and hypertension, the use of antiaggregant agents, symptom-treatment interval, hyperglycemia at the time of arrival, high value of the National Institutes of Health Stroke Scale, the presence of dense artery in first cranial computerized tomography, the size of the ischemic infarct were determined as risk factors. Also, our results showed that hyperglycemia and high blood pressure was associated with parenchymal hemorrhage