Add to ORKGRecent advances in cancer genomics have revolutionized the characterization and classification of medulloblastomas. According to the current WHO guidelines, medulloblastomas are now classified into the following molecularly defined groups: Wnt signaling pathway (WNT)-activated, sonic hedgehog signaling pathway (SHH)-activated and tumor suppressor protein p53 (TP53)-mutant, SHH-activated and TP53-wildtype, and non-WNT/non-SHH (i.e. group 3 and group 4). Importantly, genomic, epigenomic, and proteomic advances have created a potential paradigm shift in therapeutic options. The challenge now is to (i) translate these observations into new therapeutic approaches and (ii) employ these observations in clinical practice, utilizing the classificati...
The past decade has brought a wealth of information about the genetic and molecular characteristics ...
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have ide...
In this issue of Cancer Cell, Kool and colleagues reveal clear genetically defined subclasses of the...
Background: Children with medulloblastoma have a 72% chance of surviving more than 5 years under cur...
Medulloblastoma (MB) is the most common malignant pediatric posterior fossa tumor. Recent genetic, e...
Abstract SHH‐activated medulloblastomas (SHH‐MB) account for 25–30% of all medulloblastomas (MB) and...
Purpose: To present an assortment of molecular targets evident from a variety of signal transduction...
Medulloblastoma is curable in approximately 70% of patients. Over the past decade, progress in impro...
Medulloblastoma is the most common malignant brain tumor in children. Despite recent improvements in...
BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. Despite recent imp...
Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in impr...
A recent paradigm shift in the diagnostics of medulloblastoma allowed the distinction of four major ...
Medulloblastoma is curable in approximately 70% of patients. Over the past decade, progress in impro...
Medulloblastoma is a rare malignancy of the posterior cranial fossa. Although until now considered a...
Medulloblastoma is the most common malignant tumor of central nervous system in children. Patients a...
The past decade has brought a wealth of information about the genetic and molecular characteristics ...
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have ide...
In this issue of Cancer Cell, Kool and colleagues reveal clear genetically defined subclasses of the...
Background: Children with medulloblastoma have a 72% chance of surviving more than 5 years under cur...
Medulloblastoma (MB) is the most common malignant pediatric posterior fossa tumor. Recent genetic, e...
Abstract SHH‐activated medulloblastomas (SHH‐MB) account for 25–30% of all medulloblastomas (MB) and...
Purpose: To present an assortment of molecular targets evident from a variety of signal transduction...
Medulloblastoma is curable in approximately 70% of patients. Over the past decade, progress in impro...
Medulloblastoma is the most common malignant brain tumor in children. Despite recent improvements in...
BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. Despite recent imp...
Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in impr...
A recent paradigm shift in the diagnostics of medulloblastoma allowed the distinction of four major ...
Medulloblastoma is curable in approximately 70% of patients. Over the past decade, progress in impro...
Medulloblastoma is a rare malignancy of the posterior cranial fossa. Although until now considered a...
Medulloblastoma is the most common malignant tumor of central nervous system in children. Patients a...
The past decade has brought a wealth of information about the genetic and molecular characteristics ...
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have ide...
In this issue of Cancer Cell, Kool and colleagues reveal clear genetically defined subclasses of the...