Bacteriological Profile of Blood Culture Positive Sepsis in Newborn at BPKIHS, Dharan Nepal

<p><strong>Background &amp; Objectives:</strong> Neonatal infections currently cause about 1.6 million deaths annually in developing countries. Sepsis and meningitis is responsible for most of these deaths. This study was undertaken to determine the bacteriological profiles and antibiotic sensitivity patterns of isolates from blood cultures of neonates admitted in a tertiary care hospital in Eastern Nepal.</p><p><strong>Materials &amp; Methods:</strong> A retrospective study was conducted at pediatric department from January, 2014 to December 2014. Total 1009 newborns blood sample with suspected and clinical sepsis were cultured by using standard microbiological technique and antibiotic sensitivity patterns were studied. </p><p><strong>Results:</strong> The positive blood culture was 32.4% (327/1009). Gram positive bacteria were more common 231(71%) than gram negative bacteria 96(29%). Staphylococcus aureus 174 (53.2%) and acinetobacter 46(14.1%) were the commonest isolates in blood culture. Most of the organisms showed sensitivity with aminoglycosides (gentamicin and amikacin) and third generation cephalosporins.</p><p><strong>Conclusion:</strong> Staphylococcus aureus, Acinetobacter and Klebsiella species remain the principal organisms causing neonatal sepsis and antibiotics like amino glycosides should be first choice of drugs.