Alternative splicing is considered a major mechanism for creating multicellular diversity from a limited repertoire of genes. Here, we performed the first study of genetic variation controlling alternative splicing patterns by comprehensively identifying quantitative trait loci affecting the differential expression of transcript isoforms in a large recombinant inbred population of Caenorhabditis elegans, using a new generation of whole-genome very-high-density oligonucleotide microarrays. Using 60 experimental lines, we were able to detect 435 genes with substantial heritable variation, of which 36% were regulated at a distance (in trans). Nonetheless, we find only a very small number of examples of heritable variation in alternative splici...
Complex traits, including common disease-related traits, are affected by many different genes that f...
Background: Alternative RNA splicing allows cells to produce multiple protein isofo...
Recent genetical genomics studies have provided intimate views on gene regulatory networks. Gene exp...
Alternative splicing is considered a major mechanism for creating multicellular diversity from a lim...
Normal development requires the right splice variants to be made in the right tissues at the right t...
Studying genetic variation of gene expression provides a powerful way to unravel the molecular compo...
Alternative splicing is a tightly regulated biological process by which the number of gene products ...
Technological advancements have sparked discovery in biology, enabling important questions to be add...
Alternative splicing has the potential to increase the diversity of the transcriptome and proteome. ...
The study of expression quantitative trait loci (eQTL) using natural variation in inbred populations...
RNA splicing generates multiple transcript isoforms from a single gene and enhances the complexity o...
Many genes are known to produce more than one form of mRNA by alternative splicing, in which exons a...
Background: alternative splicing diversifies the pool of messenger RNA molecules encoded by individu...
Complex traits, including common disease-related traits, are affected by many different genes that f...
Complex traits, including common disease-related traits, are affected by many different genes that f...
Background: Alternative RNA splicing allows cells to produce multiple protein isofo...
Recent genetical genomics studies have provided intimate views on gene regulatory networks. Gene exp...
Alternative splicing is considered a major mechanism for creating multicellular diversity from a lim...
Normal development requires the right splice variants to be made in the right tissues at the right t...
Studying genetic variation of gene expression provides a powerful way to unravel the molecular compo...
Alternative splicing is a tightly regulated biological process by which the number of gene products ...
Technological advancements have sparked discovery in biology, enabling important questions to be add...
Alternative splicing has the potential to increase the diversity of the transcriptome and proteome. ...
The study of expression quantitative trait loci (eQTL) using natural variation in inbred populations...
RNA splicing generates multiple transcript isoforms from a single gene and enhances the complexity o...
Many genes are known to produce more than one form of mRNA by alternative splicing, in which exons a...
Background: alternative splicing diversifies the pool of messenger RNA molecules encoded by individu...
Complex traits, including common disease-related traits, are affected by many different genes that f...
Complex traits, including common disease-related traits, are affected by many different genes that f...
Background: Alternative RNA splicing allows cells to produce multiple protein isofo...
Recent genetical genomics studies have provided intimate views on gene regulatory networks. Gene exp...