For efficient delivery of required genetic elements we utilized high-capacity adenoviral vectors in the past allowing high transgene capacities of up to 36 kb. Previously we explored the hyperactive Sleeping Beauty (SB) transposase (HSB5) for somatic integration from the high-capacity adenoviral vectors genome. To further improve this hybrid vector system we hypothesized that the previously described hyperactive SB transposase SB100X will result in significantly improved efficacies after transduction of target cells. Plasmid based delivery of the SB100X system revealed significantly increased integration efficiencies compared with the previously published hyperactive SB transposase HSB5. After optimizing experimental setups for high-capacit...
Molecular medicine has entered a high-tech age that provides curative treatments of complex genetic ...
We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyper...
The Sleeping Beauty (SB) transposon is a non-viral integrating vector system with proven efficacy fo...
Recombinant adeno-associated viral (AAV) vectors have been shown to be one of the most promising vec...
<div><p>Recombinant adeno-associated viral (AAV) vectors have been shown to be one of the most promi...
<div><p>We recently developed adenovirus/transposase hybrid-vectors utilizing the previously describ...
We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyper...
We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyper...
Recombinant adeno-associated viral (AAV) vectors have been shown to be one of the most promising vec...
The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises incre...
The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raised incre...
The Sleeping Beauty (SB) transposon is a promising technology platform for gene transfer in vertebra...
International audienceThe Sleeping Beauty (SB) transposon is a non-viral integrating vector system w...
Recent results confirm that long-term expression of therapeutic transgenes can be achieved by using ...
<div><p>The <i>Sleeping Beauty</i> (SB) transposon is a non-viral integrating vector system with pro...
Molecular medicine has entered a high-tech age that provides curative treatments of complex genetic ...
We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyper...
The Sleeping Beauty (SB) transposon is a non-viral integrating vector system with proven efficacy fo...
Recombinant adeno-associated viral (AAV) vectors have been shown to be one of the most promising vec...
<div><p>Recombinant adeno-associated viral (AAV) vectors have been shown to be one of the most promi...
<div><p>We recently developed adenovirus/transposase hybrid-vectors utilizing the previously describ...
We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyper...
We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyper...
Recombinant adeno-associated viral (AAV) vectors have been shown to be one of the most promising vec...
The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises incre...
The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raised incre...
The Sleeping Beauty (SB) transposon is a promising technology platform for gene transfer in vertebra...
International audienceThe Sleeping Beauty (SB) transposon is a non-viral integrating vector system w...
Recent results confirm that long-term expression of therapeutic transgenes can be achieved by using ...
<div><p>The <i>Sleeping Beauty</i> (SB) transposon is a non-viral integrating vector system with pro...
Molecular medicine has entered a high-tech age that provides curative treatments of complex genetic ...
We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyper...
The Sleeping Beauty (SB) transposon is a non-viral integrating vector system with proven efficacy fo...