Preemptive Ropivacaine Local Anaesthetic Infiltration Versus Postoperative Ropivacaine Wound Infiltration in Mastectomy: Postoperative Pain and Drain Outputs

The aim of this study was to investigate if preemptive local infiltration (PLA) with ropivacaine could improve postoperative pain and determine its effect on drain output postmastectomy with axillary dissection. Methods: This was a prospective, randomized trial comprising 30 women allocated to two groups: one to receive postoperative wound infiltration (POW) of 20 mL of 0.2% (40 mg) ropivacaine (Naropin(r)) versus PLA with 20 mL of 0.2% ropivacaine (Naropin(r)) diluted with 80 mL of 0.9% saline, total volume 100 mL. A visual analogue scale (0-100 mm) and angle of shoulder abduction were used for evaluation of pain. Postoperatively, all patients received oral ibuprofen 400 mg tds. Results: There was no significant difference in postoperative pain for the first 3 days between the two groups. There were wider shoulder abduction angles in the 1st and 3rd postoperative days in the PLA group, but this was not significant. Operative time was significantly shorter in the PLA group than in the POW group (69.34 ± 59.37 minutes vs. 109.67 ± 26.96 minutes; p = 0.02). The axillary drain was removed earlier in the preemptive group, 5.4 ± 1.55 days versus 6.8 ± 2.04 days in the postoperative group (p = 0.04). Conclusion: We found no difference in postoperative pain between preemptive tumescent ropiva-caine infiltration and postoperative ropivacaine wound infiltration