Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin chains. Laminin-332 modulates epithelial cell processes, such as adhesion, migration, and differentiation and is prominent in many embryonic and adult tissues. In skin, laminin-332 is secreted by keratinocytes and is a key component of hemidesmosomes connecting the keratinocytes to the underlying dermis. In mice, lack of expression of any of the three Laminin-332 chains result in impaired anchorage and detachment of the epidermis, similar to that seen in human junctional epidermolysis bullosa, and death occurs within a few days after birth. To bypass the early lethality of laminin-332 deficiency caused by the knockout of the mouse laminin γ2 ...
Laminin alpha 5 is broadly expressed in the epidermal basement membrane (BM) of mature mice and its ...
Laminin 332, composed of the a3, b3 and c2 chains, is an epithelial-basement membrane specific lamin...
Laminin-332 (α3ß3γ2) (Lm332) supports the stable anchoring of basal keratinocytes to the epidermal b...
Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin ...
Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin ...
The skin epidermis is attached to the underlying dermis by a laminin 332 (Lm332)-rich basement membr...
Junctional forms of epidermolysis bullosa (JEB) are associated with mutations in six distinct genes ...
International audienceLaminin 332, with chain composition α3β3γ2, is a component of basement membran...
Laminin 332, composed of the α3, β3 and γ2 chains, is an epithelial-basement membrane specific lamin...
Laminins are the most abundant non-collagenous basement membrane (BM) components, composed of an a, ...
Genetic, clinical, and biochemical studies have shown that integrity of the dermal-epidermal junctio...
Laminins (LMs) are essential components of all basement membranes where they regulate an extensive a...
The current expansion of autologous human keratinocytes to resurface severe wound defects still reli...
Laminin-5 is composed of three distinct polypeptides, alpha3, beta3, and gamma2, which are encoded b...
Junctional epidermolysis bullosa (JEB) is an inherited mechanobullous disease characterized by reduc...
Laminin alpha 5 is broadly expressed in the epidermal basement membrane (BM) of mature mice and its ...
Laminin 332, composed of the a3, b3 and c2 chains, is an epithelial-basement membrane specific lamin...
Laminin-332 (α3ß3γ2) (Lm332) supports the stable anchoring of basal keratinocytes to the epidermal b...
Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin ...
Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin ...
The skin epidermis is attached to the underlying dermis by a laminin 332 (Lm332)-rich basement membr...
Junctional forms of epidermolysis bullosa (JEB) are associated with mutations in six distinct genes ...
International audienceLaminin 332, with chain composition α3β3γ2, is a component of basement membran...
Laminin 332, composed of the α3, β3 and γ2 chains, is an epithelial-basement membrane specific lamin...
Laminins are the most abundant non-collagenous basement membrane (BM) components, composed of an a, ...
Genetic, clinical, and biochemical studies have shown that integrity of the dermal-epidermal junctio...
Laminins (LMs) are essential components of all basement membranes where they regulate an extensive a...
The current expansion of autologous human keratinocytes to resurface severe wound defects still reli...
Laminin-5 is composed of three distinct polypeptides, alpha3, beta3, and gamma2, which are encoded b...
Junctional epidermolysis bullosa (JEB) is an inherited mechanobullous disease characterized by reduc...
Laminin alpha 5 is broadly expressed in the epidermal basement membrane (BM) of mature mice and its ...
Laminin 332, composed of the a3, b3 and c2 chains, is an epithelial-basement membrane specific lamin...
Laminin-332 (α3ß3γ2) (Lm332) supports the stable anchoring of basal keratinocytes to the epidermal b...