Hadrons carrying heavy quarks, i.e. charm or bottom, are important probes of the hot and dense medium created in relativistic heavy ion collisions. Heavy quarkantiquark pairs are mainly produced in initial hard scattering processes of partons. While some of the produced pairs form bound quarkonia, the vast majority hadronize into particles carrying open heavy flavor. Heavy quark production has been studied by the PHENIX experiment at RHIC via measurements of single leptons from semi-leptonic decays in both the electron channel at mid-rapidity and in the muon channel at forward rapidity. A large suppression and azimuthal anisotropy of single electrons have been observed in Au + Au collisions at 200 GeV. These results suggest a large energy l...